prophylactic effect of zinc sulphate on hyperbilirubinemia in premature very low birth weight neonates: a randomized clinical trial

introduction: one of the common problems in neonatal period is jaundice that occurs in the first week of birth in 60% of term and 80% of preterm neonates. in preterm newborn hyperbilirubinaemia is higher, persistent, longer, and more likely to be associated with neurological injury than term neonates. the purpose of this study was to determine prophylactic effect of zinc sulphate on hyperbilirubinemia in premature very low birth weight neonates. method and material: sixty newborns who admitted in our nicu which had inclusion criteria were eligible in this trial. included neonates were randomly placed in two groups (case and control) and before intervention the total serum bilirubin (tsb) was measured at second day. the participant received either 20 mg of zinc sulfate or placebo through ng-tube divided in two doses till day seven of age. then total and indirect bilirubin was measured at 3ed, 5th and 7th day of life. if any of newborns in duration of hospitalization develop clinical jaundice, after assessment of bilirubin, need for phototherapy was evaluated based on phototherapy and exchange schedule as described by the american academy of pediatrics guidelines. the termination point of phototherapy was defined as a bilirubin level less than 50 percent of starting point. after gathering data, they were analyzed using spss software (version 11.5) and t-test, chi-square and repeated measurement tests. results: seventy eight patients enrolled in this trial that 18 cases were excluded and the remaining cases divided into two equal groups (n=30 in each group). demographic condition was similar in two groups. there were no different between two groups in decreasing total serum bilirubin and duration of phototherapy. conclusion: this study showed that zinc sulfate has no preventing effective in hyperbilirubinemia in preterm very low birth weight neonates. it has also no effect on duration of phototherapy.